ABSTRACT
Objective:The process of myocardial infarction is generally characterized by the activation of host immune cells and the occurrence of inflammation. However, it is unknown which immune cells are preferentially activated and participated into the progression of myocardial infarction. Methods:A total of 55 patients with myocardial ischemia including 13 of stable angina ( SA) ,25 of unstable angina (UA) and 17 of acute myocardial infarction (AMI) as well as 12 of healthy controls (HCs) were enrolled in the study. The frequency and the immune activation marker CD38 expression by peripheral CD3 T cells,CD4 T cells,CD8 T cells,CD4+NKT cells, CD4- NKT cells, CD3-CD56+ NK cells and B cells were comprehensively analyzed. Results:There was no significant difference in the frequencies of these immune cell subsets in peripheral blood among these four groups. Importantly,it was found that CD38 expression was significantly increased on CD8 T cells,NKT cells and NK cells in patients with acute coronary syndromes ( ACS) including UA and AMI patients as compared with those in SA and HC subjects. These data indicated that multiple immune cells were activated in ACS patients,which were possibly participated into the pathogenesis of ACS. Conclusion:The activation of multiple immune cells was closely associated with the progression and outcome in ACS patients. This study provides immune hyper-activation mechanism underlying the development of ACS and may favor for finding a novel immune marker to predict the progression of ACS.
ABSTRACT
BACKGROUND: It is discovered in clinical practice that the principles of regaining consciousness, opening orifice combining with benefiting qi and nourishing yin for the treatment of both root causes and symptoms can improve remarkably neurological functional recovery in acute stage of cerebral infarction.OBJECTIVE: To observe the effects of xingnaojing injection and angong niuhuang wan on neurological functional disturbance in acute stage of cerebral infarction.DESIGN: Randomized controlled study based on patients.SETTING: Guangdong General Hospital of Chinese People' s Armed Police Force.PARTICIPANTS: Inpatients with cerebral infarction in Department of Neurology of Guangdong General Hospital, Chinese People' s Armed Police Force from September 1998 to September 2003.METHODS: Totally 120 cases in the acute stage of cerebral infarction were randomized into xingnaojing injection group(XNJ), angong niuhuang wan (ANW) group and danshen fen(DSF) group, 40 cases in each group. Fourteen days after treatment, the therapeutic effects and neurological functional improvement were observed.MEAN OUTCOME MEASURES: Comparison of the improvement in neurological function in groups was carried on in the experiment. RESULTS: The total effective rates were 95%, 90% and 65% in xingnaojing injection group, angong niuhuang wan group and danshen fen group successively. The paralysis of limb was recovered more markedly in xingnaojing injection group and angong niuhuang wan group compared with the control. The therapeutic effect was significant in xingnaojing injection group.CONCLUSION: Both xingnaojing injection group and angong niuhuang wan group treat cerebral infarction of acute stage with better therapeutic effects, and the former provides rather remarkable effect on the recovery of neurological functional defect.